Figure 4.

Ganaxolone (GNX) 5 mg/kg by subcutaneous injection daily for 1 week following preterm birth restores mature myelin coverage in (A) the CA1 region of the hippocampus, and (B) the overlying subcortical white matter at childhood-equivalent age (corrected postnatal day 28). Behavior was also restored toward a term born phenotype for (C) the distance traveled, and (D) the time spent mobile in the open field arena. (*p < 0.05, n = 4–10). Adapted from (55).