Table 1.
Studies exploring the diagnostic accuracy of USPIO-enhanced MRI for nodal detection in HNSCC.
| Author | Year | Number of nodes in analysis | Number of patients in analysis | Clinical N-stage | Dose (mg Fe/kg body weight) | MRI field strength in Tesla (no.) | MRI timing in hours | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Anzai (45) | 1994 | 91 | 11 | n.p. | 1.7 | 1.5 | 10–12 (4) 22–24 (8) 48 (2) a |
95 | 84 | n.p. | n.p. |
| Hoffman (46) | 2000 | 101 | 9 | 8/9 cN+ 1/9 cN- |
1.7 | 1.5 | 24–36 | 95 | 99 | n.p. | n.p. |
| Mack (21) | 2002 | 1029 | 27 | 29/30 cN+ 1/30 cN- |
2.6 | 1.5 | 24–36 | 86 | 100 | 100 | 99 |
| Sigal (38) | 2002 | 86 | 81 | 53/81 cN+ 28/81 cN- |
2.6 | 1.5 (78) 1.0 (3) |
24–36 | ≥ 88 | ≥ 77 | ≥ 51 | ≥ 90 |
| Anzai (47) | 2003 | n.p. | 29 | n.p. | 2.6 | n.p. | 24–36 | 96 | 87 | n.p. | n.p. |
| Baghi (48) | 2005 | 363 | 26 | 17/28 cN+ 11/28 cN- |
2.6 | 1.5 | 24–36 | 82.3 | 100 | 100 | 93 |
| Curvo-Semedo (49) | 2006 | 63 | 19 | 13/20 cN+ 7/20 cN- |
2.6 | 1.5 | 24–36 | 96 | 78.9 | 75 | 96.8 |
| Baghi (50) | 2007 | 80 | 17 | 8/17 cN+ 9/17 cN- |
2.6 | n.p. | 24–36 | n.p. | 94 | n.p. | n.p. |
| Wensing (51) | 2011 | 143 | 9 | 0/9 cN+ 9/9 cN- |
2.6 | 1.5 3.0 |
24–36 | 100 (1.5T) | 92 (1.5 T) | 8 (1.5 T) | 100 (1.5 T) |
| 3.0 | 24–36 | 100 | 93 | 9&10 | 100 |
a
2 patients underwent MRI twice at 10 and 24 h.
cN-, clinically node negative; cN+, clinically node positive; Fe, iron; kg, kilogram; MRI, magnetic resonance imaging; N, node; mg, milligram; n.p., not provided; n.s., not specified; no., number of patients; NPV, negative predictive value; PPV, positive predictive value.