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STING is essential for intracellular DNA-dependent IFN-I transcription in HD11 cells. (A) Example of identification of indel in clonally selected HD11 STING KO using NGS sequencing. (B) WT and STING KO HD11 cells were transfected with HT-DNA, CT-DNA (2 μg/ml) or Poly(I:C) (1 μg/ml) for 6 h and transcription of the indicated genes measured by qRT-PCR 6 h later. *p < 0.05, ***p < 0.001; 2difference. Data is representative of two or more replicates.
