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. 2021 Jan 28;8:602707. doi: 10.3389/fcell.2020.602707

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Copyright © 2021 Mao, Li, Hua, Gu, Pan, Chen, Xu, Lu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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circPDHX promoted prostate cancer (PCa) cell proliferation, colony formation, and cell invasion. (A) Quantitative real-time PCR (qRT-PCR) analysis of the expression levels of circPDHX after transfection with si-circPDHX or circPDHX plasmids in 22RV1 and PC3 cell lines. (B,C) 3-(4,5-Dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) analysis of the cell proliferation after transfection with si-circPDHX or circPDHX plasmids in 22RV1 and PC3 cell lines. (D,E) Transwell analysis of cell invasion after transfection with si-circPDHX or circPDHX plasmids in 22RV1 and PC3 cells. (F,G) Colony formation analysis of the cell colony formation abilities after transfection with si-circPDHX or circPDHX plasmids in 22RV1 and PC3 cell lines. Data shown are the mean ± SEM of three experiments. *P < 0.05; **P < 0.01.