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. 2021 Feb 2;9:627102. doi: 10.3389/fcell.2021.627102

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Copyright © 2021 Cui, Huang, Sun, Ning, Mu, You, Guo, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed model of the mechanism for the transcriptional regulation of the P1 promoter and adipogenesis by KLF2. KLF2 directly binds to the unmethylated and methylated P1 promoter of the chicken PPARγ gene with unknown cofactors (X), and recruit HMT and HDAC to the P1 promoter, which cause increased H3K9me2 and decreased H3K27ac, leading to inhibition of PPARγ1 expression and adipogenesis.