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. 2021 Jan 28;8:611149. doi: 10.3389/fbioe.2020.611149

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Copyright © 2021 Zambrano, McLean, Zhao, Tan, Zhong, Figueroa, Lee and Baek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Color-coded spatial distribution of TAWSS for all subjects (control and PAH) arranged with increasing linearized stiffness E. (B) Averaged TAWSS (over the entire model) as a function of E showing a weaker correlation (r = −0.646; P = 0.032) and a stronger correlation (r = −0.746; R = 0.088) in all and only PAH subjects, respectively. Control (white) and PAH (gray). (C) Comparison of TAWSS averaged over the MPA (control: median: 1.56 Pa, IQR: 0.89 Pa vs. PAH: median: 0.81 Pa, IQR: 0.47 Pa) and over the entire model (median: 1.32 Pa, IQR: 0.69 Pa vs. median: 2.12 Pa, IQR: 1.66 P; P = 0.062) between PAH and control groups.