Table 1.
Demographics and clinical examinations in PAH and normal control subjects**.
| Variables | Control (n = 5) | PAH (n = 6) | P value |
|---|---|---|---|
| Demographics | |||
| Age, years | 51 ± 15 | 50 ± 11 | 0.792 |
| Gender, male/female | 1/5 | 1/4 | 0.727 |
| Weight, kg | 66 ± 18 | 61 ± 10 | 0.662 |
| Height, cm | 160 ± 8 | 162 ± 6 | 0.792 |
| Clinical Exam | |||
| Body surface area, m2 | 1.70 ± 0.26 | 1.65 ± 0.12 | 0.931 |
| Body mass index, kg/m2 | 25.2 ± 4.3 | 23.2 ± 4.7 | 0.177 |
| 6-min walking test, m | – | 391 ± 103 | – |
| NYHA functional class I, n | – | 1 | – |
| NYHA functional class II, n | – | 4 | – |
| NYHA functional class III, n | – | 1 | – |
| NYHA functional class IIII, n | – | 0 | – |
| Cardiac magnetic resonance | |||
| LV ejection fraction, % | 64 ± 6 | 60 ± 8 | 0.329 |
| LVEDV, ml | 111 ± 15 | 113 ± 18 | 0.931 |
| LVESV, ml | 40 ± 8 | 46 ± 14 | 0.792 |
| LVSV, ml | 71 ± 11 | 67 ± 12 | 0.537 |
| RV ejection fraction, % | 60 ± 9 | 45 ± 17 | 0.177 |
| RVEDV, ml | 118 ± 24 | 189 ± 114 | 0.537 |
| RVESV, ml | 49 ± 18 | 119 ± 104 | 0.329 |
| RVSV, ml | 69 ± 12 | 71 ± 16 | 0.931 |
| Hemodynamics | |||
| Heart rate, bpm | 81 ± 17 | 71 ± 16 | 1 |
| Diastolic blood pressure, mmHg | 80 ± 17 | 74 ± 10 | 0.792 |
| Systolic blood pressure, mmHg | 137 ± 21 | 130 ± 30 | 0.537 |
| Cardiac output, l/min | – | 5.01 ± 3.32 | – |
| Cardiac index, l/min/m2 | – | 2.98 ± 1.64 | – |
| Right atrial pressure, mmHg | – | 6 ± 6 | – |
| Mean pulmonary artery pressure, mmHg | – | 38 ± 8 | – |
| Pulmonary capillary wedge pressure, mmHg | – | 12 ± 1 | – |
| Systemic vascular resistance, dyne s/cm5 | – | 1,948 ± 750 | – |
| Total pulmonary vascular resistance, dyne s/cm5 | – | 588 ± 228 | – |
| Pulmonary systemic flow ratio | – | 0.98 ± 0.12 | – |
| Pulmonary and systemic resistance ratio | – | 0.33 ± 0.11 | – |
**
Cohort is a subset from a previous analysis (Finsberg et al., 2019). LV, left ventricle; LVEDV, left ventricle end-diastolic volume; LVESV, left ventricle end-systolic volume; LVSV, left ventricle stroke volume; RV, right ventricle; LVEDV, right ventricle end-diastolic volume; LVESV, right ventricle end-systolic volume; LVSV, right ventricle stroke volume.