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. 2021 Jan 28;9:632753. doi: 10.3389/fbioe.2021.632753

Table 2.

Selected examples of iCVD layers for controlled release.

Polymer composition As-deposited thickness (nm) Substrate Permeant References
NEUTRAL HYDROGELS
P(HEMA-co-EGDA) 40 Porous alumina membranes Fluorescein (dye) Ozaydin-Ince et al., 2011
P(HEMA-co-EGDMA) 30–60 Porous alumina membranes Phloroglucinol (dye) Armagan and Ozaydin Ince, 2015
P(HEMA-co-EGDMA) 200 Solid drug layer on a planar substrate Indomethacin (pain relief) Christian et al., 2018
P(HEMA-co-EGDMA) 200–500 PET, cotton fabric, polycaprolactone nanofiber mats Indomethacin (pain relief) Ghasemi-Mobarakeh et al., 2019
P(HEMA-co-EGDMA) 200 solid drug layer on a planar substrate Clotimazole (antifungal) Christian et al., 2016
P(HEMA-co-EGDMA) 1,000 Free-standing films released from polyacrylic acid sacrificial layer Alizarin yellow; phloroglucinol; 4-phenyldiphenylamin (dyes) Tufani and Ince, 2015
pH RESPONSIVE
P(MAA-co-EA) 70–400 ibuprofen microcrystals ibuprofen (pain relief) Lau and Gleason, 2007
P(MAA-co-EDMA) 340 Porous silicon loaded with drug Camptothecin (cancer treatment) McInnes et al., 2012
P(MAA-co-EGDMA) 200 Solid drug layer on a planar substrate, cellulose membrane loaded with drug Gentamicin (antibiotic) Decandia et al., 2020
P(MAA-co-EGDMA) 200 Solid drug layer on a planar substrate Clotimazole (antifungal) Christian et al., 2016
P(MAA-co-EGDMA) 200–500 Drug loaded PET, cotton fabric, polycaprolactone nanofiber mats Indomethacin (pain relief) Ghasemi-Mobarakeh et al., 2019
P(MAA-co-DMAAm-co-DEGDVE) 70–500 AAO membranes Glucose (sugar); bovine serum albumin (protein) Tenhaeff and Gleason, 2009
P(MAH-co-MAA)
(conformal)
1,000 Drug-loaded microporous polylactide membranes Rifampicin (antibiotic) Shi et al., 2018
P(4VP-co-EGDMA) 65 Mat of polyvinyl alcohol nanofibers electrospun with RB Rose Bengal (RB) (chemotherapeutic agent) Sayin et al., 2019b
THERMALLY RESPONSIVE
P(NIPAAm-co-EGDMA) 30–60 AAO template phloroglucinol (dye) Armagan and Ozaydin Ince, 2015
P(NIPAAm-co-DEGDVE) 200 Porous silicon loaded with drug Camptothecin (cancer treatment) McInnes et al., 2016
P(NIPAAm-co-DEGDVE) 200 Solid drug layer on a planar substrate Clotimazole, indomethacin (pain relief) phenytoin Werzer et al., 2019
P(NVCL-co-DEGDVE) 10–50 Planar Eudragit layer na Muralter et al., 2019
HYDROPHOBIC ENCAPSULATION
P(CHMA-co-EDGMA) 400–600 Solid microparticles of an agrochemical Crop protection compound Bose et al., 2012a
PEGDMA 200 Solid drug layer on a planar substrate Indomethacin (pain relief) Christian et al., 2018
PEGDMA 23 Mat of gelatin nanofibers Gelatin Mansurnezhad et al., 2020
PPFDA 200 Solid drug layer on a planar substrate Clotimazole (antifungal) Christian et al., 2016