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. 2021 Feb 4;9:593677. doi: 10.3389/fcell.2021.593677

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Copyright © 2021 Tan, Shao, Teng, Liu, Li, Xue, Cao, Sun, Zhang, Han, Wu, Xu and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-143-3p is a potential miRNA target of PCAT6 in ovarian cancer. (A) Diagram showing the intersection among DE miRNAs in Si-PCAT6-transfected A2780 cells compared with Si-NC-transfected A2780 cells (determined using small-RNA sequencing); PCAT6-targeting miRNAs from the ENCORI database; and miRNAs that were significantly downregulated in multiple ovarian cancer tissues based on the GSE83693, GSE119055, and GSE131790 datasets. (B) The expression levels of six miRNAs cataloged in the ENCORI database were detected in our small-RNA sequencing data. (C) miR-143-3p was consistently and significantly downregulated in tumor tissues compared to normal tissues based on the GSE83693, GSE119055, and GSE131790 datasets. *P < 0.05.