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. 2021 Jan 28;8:605702. doi: 10.3389/fbioe.2020.605702

Figure 2.

Figure 2

Variation levels of viral load, IgM and IgG post SARS-CoV-2 infection. Data collected from Tan et al. from 67 confirmed COVID-19 patients (both mild and severe cases) (Tan et al., 2020). Viral RNA (amplified ORF1ab gene) was detected in nasopharyngeal swabs using the Qiamp® viral RNA mini kit (QIAGEN, Hilden, Germany). The viral load threshold (black dashed line) indicates the detection limit of this kit corresponding to a cycle threshold value of 38 which is equivalent to 104.577 genomic copies/mL. On the other hand, IgM & IgG titers (anti-SARS-CoV-2 nucleocapsid immunoglobulins) were analyzed in serum samples using ELISA kits (Livzon Diagnostics Inc., Zhuhai, China). The blue and red dashed lines denote the cutoff value for a positive result. The bold lines represent the trends, fitted using smoothing splines in Matlab.