Skip to main content
. 2021 Feb 9;8:610773. doi: 10.3389/fcell.2020.610773

Figure 1.

Figure 1

Conditional inactivation of Uhrf1 in either primordial or growing oocytes results in preimplantation embryo developmental arrest and female sterility in mice. (A) Histology of ovarian sections from control, Zp3-cKO, and Gdf9-cKO mice at 1, 3, and 5 months of age, respectively, stained with Hematoxylin and Eosin. Scale bars = 500 μm. (B–D) Quantitative analyses show the number of primordial follicles (PrF), primary follicles (PF), secondary follicles (SF), and antral follicles (AF) per ovary at the age of 1, 3, and 5 months, respectively. n = 3 for each genotype; data are presented as mean ± SEM. (E) Representative bright-field images show the morphology of the zygotes, two-cell embryos, four- to eight-cell embryos, morula, and blastocysts from control, Zp3-cKO, and Gdf9-cKO mice. (F) Statistical analysis of early embryos before implantation at each developmental stage. Data are presented as means ± SEM from three independent experiments. *p < 0.05.