Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 1;11:594594. doi: 10.3389/fimmu.2020.594594

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Pridans, Irvine, Davis, Lefevre, Bush and Hume

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Inferred gene expression profile of rat Kupffer cells. (A) Microarray analysis was performed on adult livers obtained from wild type, Csf1r^+/- and Csf1r^-/- rats (n = 4 per genotype). Data were RMA-normalised and analysed using Graphia. (A) The network graph generated by the Graphia analysis. Genes are coloured by clusters of co-expression. Expression profiles of clusters that contained genes specific to Kupffer cells (cluster 4), females (cluster 3) and males (cluster 7) are shown. (B) The differentially expressed genes identified by Lavin and colleagues (44) were clustered using Graphia. The graphs show expression of genes identified in the mouse Kupffer cell (KC) cluster. The genes represented by open bars or within the dotted line were common to both mouse and rat KC clusters. Rat genes denoted with an asterisk (*) have provisional or model RefSeq status on the Rat Genome Database (rgd.mcw.edu). Graphs show mean + SEM. p = 0.0007 (*** Clec4f), 0.0414 (* Folr2), 0.0024 (** Vsig4), 0.0209 (* Apoa1), and 0.0091 (** Apoc1) via an unpaired t-test.