Figure 6.

Transcriptional response of rat BMDM to LPS. Adult male rat bone marrow (BM) was differentiated into macrophages for 7 days in CSF1. RNA was isolated from BM-derived macrophages (BMDM) after culture with LPS (0, 2, 7, and 24 h) and microarray analysis was performed. Data were RMA-normalised and analysed using Graphia. The network graph generated by the Graphia analysis is shown. Genes are coloured by clusters of co-expression. Expression profiles of clusters that contained genes specific to each time point are shown. Data was obtained from three adult wild-type rats on a DA background and included two technical replicates per rat. One array replicate was also included for 0 h LPS.