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. 2021 Feb 4;8:631335. doi: 10.3389/fmed.2021.631335

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Copyright © 2021 Tassiopoulos, Mofakham, Rubano, Labropoulos, Bannazadeh, Drakos, Volteas, Cleri, Alkadaa, Asencio, Oganov, Hou, Rutigliano, Singer, Vosswinkel, Talamini, Mikell and Kaushansky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Escalated, D-dimer driven anticoagulation (ON-protocol group) is associated with improved critical laboratory values in multiorgan dysfunctions in COVID-19 intubated patients. The early start of AC in the ON-protocol group was associated with significant changes in the course of the disease in intubated patients. The green and blue lines represent the mean of D-dimer, creatinine and BUN for ON- and OFF-protocol groups over thirty days. Notice the elevated level of these laboratory values in the first two weeks following intubation, which is associated with many of mortalities in the OFF-protocol group. The shaded area represents the SE of the mean. These analyses are time-locked to the intubation date marked by the red dashed line.