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. 2021 Feb 9;8:600626. doi: 10.3389/fmed.2021.600626

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Copyright © 2021 Sullivan, Jiang, Hinchie, Roth, Bahudhanapati, Nouraie, Liu, McDyer, Mallampalli, Zhang, Kass, Finkel and Alder.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of candidate biomarkers in plasma from IPF patients and controls. (A–F) Violin plots of candidate biomarkers identified in RNA-seq and proteomic analyses that displayed statistically significance differences in patient plasma samples. Plasma from patients with IPF (n = 50) and controls (n = 30) was analyzed using a custom Luminex panel. Median and interquartile range is shown. Significance defined as P < 0.035 by Welch's t-test using the Benjamini-Hochberg procedure to correct for multiple testing while utilizing a pre-defined 10% false discovery rate.