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. 2021 Feb 5;8:624339. doi: 10.3389/fcell.2020.624339

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Copyright © 2021 Chen, Liu, Wang, Yu, Zhang, Liu, Chen, Zhu and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DAU improves the spatial learning and memory abilities of 3xTg-AD mice. (A,B) The latency in the retention test and the number of errors on the first day. (C,D) The latency in the retention test and the number of errors on the second day. (E–I) Morris water maze (MWM) test. (E) Crossing number, (F) probe time, (G) the percentage of distance traveled in the correct quadrant, (H) the percentage of time spent in the correct quadrant, and (I) the representative swimming path. Data are presented as mean ± SEM. *p < 0.05, ****p < 0.0001 vs. WT saline group. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. 3xTg-AD saline group. ^&&p < 0.01 vs. 3xTg-AD-1 mg/kg/d group. N = 10–14 for each group.