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. 2021 Feb 5;8:624339. doi: 10.3389/fcell.2020.624339

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Copyright © 2021 Chen, Liu, Wang, Yu, Zhang, Liu, Chen, Zhu and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DAU reduced the levels of Aβ and hyperphosphorylated tau in 3xTg-AD mice. (A,B) Immunohistochemical staining of the CA1, CA3, and cortex of 3xTg-AD mice with 6E10 and quantitative statistics of positive staining (n = 3 per group). (C,D) Western blot analysis for the expression level of pT231, p404, p262, p396, Tau1, and Tau5 (n = 4 per group). (E,F) Immunohistochemical staining of the CA1 region of 3xTg-AD with AT8 and quantitative statistics of positive staining (n = 3 per group). Data are presented as mean ± SEM. **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. WT vehicle group. ^#p < 0.05, ^##p < 0.01 vs. 3xTg-AD saline group. ^&p < 0.05 vs. 3xTg-AD-1mg/kg/d group.