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. Author manuscript; available in PMC: 2021 Feb 23.
Published in final edited form as: Toxicol Lett. 2019 Nov 7;319:148–154. doi: 10.1016/j.toxlet.2019.11.005

Fig. 4.

Fig. 4.

Eadie-Hofstee plot for CYP2D6 (dextromethorphan O-demethylase) activity in presence of varying concentrations of mitragynine (MTG, left panel) and corynanthedine (COR, right panel) in HLMs. The inset depicts secondary plot of Km, app versus inhibitor concentration for MTG and COR, where the slope of the line represents (Km/Ki value) while Y-intercept and X-intercept represents Km and Ki values. Each data plotted as a mean of triplicate determinations. The solid lines represent the best fit to the data using linear regression.