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. Author manuscript; available in PMC: 2021 Feb 23.
Published in final edited form as: Cancer Discov. 2020 Apr;10(4):495–497. doi: 10.1158/2159-8290.CD-20-0046

Figure 1.

Figure 1.

Schematic representation of the role of MYC as a reversible driver of cell-intrinsic and cell-extrinsic PDAC progression. Epithelial acinar-to-ductal metaplasia (ADM), pancreatic intraepithelial neoplasia (PanIN), progression to pancreatic ductal adenocarcinoma (PDAC), and reversion to PanIN and ductal-to-acinar transdifferentiation (DAT) are indicated. Desmoplastic stromal and vascular changes and immune cell infiltrates are depicted. ECM, extracellular matrix; KRAS*, mutationally activated KRAS.