Table 2.

Association between measures of adiposity and cognitive performance and change, stratified by age.

	Baseline age <65		Baseline age 65+
	Global cognition	Cognitive change	Global cognition	Cognitive change
	Beta, P-value	Beta, P-value	Beta, P-value	Beta, P-value
BMI (per SD)
Model 1	−0.030, 0.09	−0.009, 0.55	−0.011, 0.68	0.041, 0.11
Model 2	−0.025, 0.16	−0.012, 0.45	−0.009, 0.73	0.045, 0.08
Model 3	−0.011, 0.54	−0.008, 0.61	−0.011, 0.67	0.048, 0.07
Overweight
Model 1	−0.025, 0.59	−0.013, 0.75	−0.065, 0.23	−0.009, 0.87
Model 2	−0.033, 0.48	−0.025, 0.55	−0.061, 0.27	−0.014, 0.80
Model 3	−0.019, 0.68	−0.021, 0.61	−0.061, 0.27	−0.015, 0.79
Obese
Model 1	−0.092, 0.06	−0.037, 0.39	−0.059, 0.36	0.067, 0.30
Model 2	−0.077, 0.12	−0.044, 0.32	−0.049, 0.45	0.072, 0.27
Model 3	−0.043, 0.40	−0.034, 0.45	−0.053, 0.43	0.091, 0.17
Waist:hip ratio (per SD)
Model 1	−0.064, 0.002	−0.040, 0.02	−0.038, 0.12	−0.001, 0.97
Model 2	–0.062, 0.003	−0.039, 0.03	−0.035, 0.15	−0.004, 0.87
Model 3	−0.051, 0.02	−0.037, 0.04	−0.032, 0.19	0.0004, 0.99

Model 1: sex, insurance, race/ethnicity, age, education, time from baseline to MRI

Model 2: variables in model 1 + smoking, alcohol consumption, physical activity, depression

Model 3: variables in model 2 + hypertension, diabetes, hypercholesterolemia