Table 3.
Half-life and corresponding reduction factors of envelope-pseudotyped lentiviral vectors.
| Envelope protein | Average HL | Reduction factor | |
|---|---|---|---|
| (in hours) | (±SD) | (in daysa) | |
| VSV-G | 34.7 | ±0.0 | 0.7 |
| Measles | 14.1 | ±0.0 | 1.7 |
| GALV | 8.3 | ±1.0 | 2.9 |
| Rabies | 15.4 | ±1.0 | 1.6 |
| RD114 | 21.2 | ±10.5 | 1.1 |
| 4070A | 36.6 | ±2.7 | 0.7 |
| 10A1 | 13.8 | ±0.2 | 1.7 |
| MuLV | 18.6 | ±5.4 | 1.3 |
aThe reduction factor based on the half-life of the envelope-pseudotyped lentiviral vectors is represented in days to be readily applicable in the formula for the Reduction Ratio of free infectious-lentiviral vector particles. For example: 34.7 h equals 1.4 days. Reduction factor per day: 1/1.4 = 0.7.