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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Bioessays. 2020 Nov 6;43(1):e2000202. doi: 10.1002/bies.202000202

Figure 2. CreERT2-loxP approach for in vivo lineage-tracing experiments.

Figure 2.

(a) Tamoxifen administration can temporarily activate cre-loxP recombination in a target cell population, which removes “STOP” sequences in the Rosa26 reporter locus. As a result, the reporter gene becomes permanently expressed in the targeted cells.

(b) The reporter gene is continually expressed in the targeted cell and its descendants, allowing permanent marking of a given cell population.