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Schematic of the proposed regulatory dynamic between SIAH2, ZFP521, and EBF1 in promoting adipogenesis. (A) A molecular model where SIAH2-mediated degradation of ZFP521 (A) is enhanced by interaction of EBF1 with SIAH2 and ZFP521 to accelerate ZFP521 degradation. (B) Proposed sequence of SIAH2, EBF1 and ZFP521 protein interaction to promote Zfp423 and Pparg gene expression during conversion of precursor cells to mature adipocytes.
