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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: J Am Geriatr Soc. 2020 Oct 5;69(2):365–372. doi: 10.1111/jgs.16853

Figure 2: Vitamin D-increasing genetic variants associated with reduced likelihood of incident delirium diagnosis.

Figure 2:

A) Six genetic variants are known to affect circulating 25(OH)D (vitamin D) levels (effect shown on the x-axis). We determined the association with risk of incident delirium for each genetic variant (shown on the y-axis). Mendelian randomization penalized robust inverse-weighted regression (MR-IVW) results (including 95% Confidence Intervals) show that genetic predisposition to higher serum vitamin D is associated with reduced likelihood of delirium diagnosis in the follow-up. B) Radial IVW plot of results using modified second-order weights (no significant outliers were detected). C) Radial MR-Egger funnel plot showing the regression intercept is not significantly different from the null (no evidence of pleiotropy).