Table 5.

Multivariable predictors of severe AKI after IHCA in cardiac patients at four time points

	Through Step 1 Model AUC = 68.8%		Through Step 2 Model AUC = 75.7%		Through Step 3 Model AUC = 80.8%		Through Step 4 Model AUC = 83.2%
Predictors¹	Odds Ratio (95% CI)	P-value	Odds Ratio (95% CI)	P-value	Odds Ratio (95% CI)	P-value	Odds Ratio (95% CI)	P-value
Step 1: Pre-arrest
Preexisting congenital heart disease	0.18 (0.06, 0.55)	0.003	0.19 (0.06, 0.61)	0.005	0.21 (0.06, 0.70)	0.01	0.16 (0.04, 0.60)	0.007
Patient post-operative cardiac surgery	4.20 (2.12, 8.32)	<.001	3.75 (1.84, 7.63)	<.001	4.05 (1.90, 8.62)	<.001	3.44 (1.59, 7.44)	0.002
Step 2: At time of ROC
Estimated duration of chest compressions			1.02 (1.01, 1.04)	0.001	1.01 (1.00, 1.03)	0.07	1.01 (0.99, 1.02)	0.23
Step 3: Post-arrest, near interv ention start
Baseline Lactate² (mmol/L)					1.14 (1.06, 1.23)	<.001	1.15 (1.06, 1.24)	<0.001
Step 4: Day 0–1
Minimum percentile of gender/height-adjusted systolic blood pressure							0.97 (0.95, 0.99)	0.008

Predictors considered for logistic regression models: age, preexisting lung or airway disease, preexisting arrhythmia, preexisting congenital heart disease, preexisting renal condition, post-operative cardiac surgery, aetiology of arrest, doses of adrenaline, estimated duration of chest compressions, extracorporeal membrane oxygenation (ECMO) used, baseline lactate, packed red blood cells (PRBC) volum e (cc/kg) per day (day 0 and 1), minimum percentile of gender/height-adjusted systolic blood pressure, milrinone used (day 0 or 1), vasopressin used (day 0 or 1), adrenaline used (day 0 or 1), dopamine used (day 0 or 1), phenylephrine used (day 0 or 1).

First non-missing lactate value occurring ≤ 8 hours after randomization.