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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Stroke. 2021 Feb 10;52(3):1154–1161. doi: 10.1161/STROKEAHA.120.031939

Table 2.

Potential advantages and disadvantages of using domain-specific endpoints in acute stroke trials

Advantages

  1. Increased resolution of measurement

  2. Greater insight into acute therapy effects on individual brain systems

  3. Foster a common language across all stroke trials

  4. Better understanding of treatment mechanism

  5. Better understanding of what goes on in the brain from acute treatment to day-90

  6. Optimizing therapeutic translation

  7. Support therapeutic targeting of individual neural systems acutely

  8. Capture improved outcomes in additional, patient-centered dimensions

Disadvantages

  1. Can require longer times to administer

  2. Some domain-specific endpoints require specific testing equipment

  3. Some domain-specific endpoints require specially trained personnel

  4. Incomplete knowledge exists for the natural history of some domain-specific endpoints

  5. Some domain-specific endpoints require further study of psychometric qualities such as validity

  6. Experience remains limited for some domain-specific endpoints

  7. Incorporating multiple domain-specific endpoints can increase risk of a type I error