Table 2.
Interaction of cerebral vessel pathology with β-amyloid/ PHF-tau tangle burden in relation to probability of microinfarct burden.
| Model Set | Predictors | Interaction | Cortical microinfarcts | Subcortical microinfarcts |
|---|---|---|---|---|
| 1 | Arteriolosclerosis | −0.10 (0.14,0.48) | 0.35 (0.14,0.01) | |
| β-amyloid | −0.12 (0.11,0.26) | 0.09 (0.12,0.48) | ||
| Arteriolosclerosis x β-amyloid | 0.15 (0.07,0.02) | 0.02 (0.07,0.73) | ||
| 2 | CAA | −0.29 (0.14,0.05) | −0.05 (0.15,0.76) | |
| β-amyloid | −0.24 (0.11,0.03) | 0.04 (0.11,0.73) | ||
| CAA x β-amyloid | 0.27 (0.07, <0.001) | 0.02 (0.08,0.84) | ||
| 3 | Arteriolosclerosis | −0.06 (0.12,0.64) | 0.11 (0.13,0.39) | |
| PHF-tau | −0.22 (0.10,0.03) | −0.34 (0.13,0.01) | ||
| Arteriolosclerosis x PHF-tau | 0.13 (0.06,0.02) | 0.13 (0.07,0.04) | ||
| 4 | CAA | −0.10 (0.12,0.40) | 0.09 (0.13,0.49) | |
| PHF-tau | −0.36 (0.13,0.01) | −0.01 (0.13,0.93) | ||
| CAA x PHF-tau | 0.16 (0.06,0.005) | −0.08 (0.07,0.27) |
Log-odds ratio estimates were derived from logistic regression models in which cortical microinfarct burden was the outcome. Models included an interaction term between vessel pathologies, either CAA or arteriolosclerosis, and β-amyloid or tau tangle burden. All model sets were adjusted for age, sex, education, and atherosclerosis. In addition, model set 1 was further adjusted for CAA and tangle burden. Model set 2 for arteriolosclerosis and tangles. Model set 3 for CAA and β-amyloid. Model set 4 for arteriolosclerosis and β-amyloid. Cell value represents log-odds estimate (SE, p-value).