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. Author manuscript; available in PMC: 2021 Feb 24.
Published in final edited form as: Clin Pharmacol Ther. 2020 Oct 8;109(1):73–81. doi: 10.1002/cpt.2028

Figure 4.

Figure 4

Bayesian estimation of hydroxyurea pharmacokinetic (PK) profile. The figure illustrates a representative hydroxyurea PK profile re-constructed using Bayesian approach (blue line) vs. population model prediction (teal dashed line). In this young child of 7 months old, Bayesian algorithm generated an area under the concentration-time curve (AUC) prediction of 75 mg*hour/L (blue line), which is slightly different from model prediction (teal dashed line). Based on the exposure target of 115 mg*hour/L, an optimal starting dose of 30.2 mg/kg was selected to achieve the target.