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Interpatient variability in hydroxyurea pharmacokinetics (PKs) and benefits of Bayesian adaptive control. There is significant interpatient variability in hydroxyurea PKs with individual area under the concentration-time curves (AUCs) ranging from 40 to 140 mg*hour/L. Bayesian estimation of AUC for individual patients demonstrates a more accurate estimation of individual hydroxyurea exposure than the population model alone.
