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. Author manuscript; available in PMC: 2022 Feb 23.
Published in final edited form as: Circulation. 2020 Dec 3;143(8):790–804. doi: 10.1161/CIRCULATIONAHA.120.047987

Figure 4. Outcomes according to treatment strategy and MI definition.

Figure 4.

Figure 4.

Figure 4.

Figure 4.

Unadjusted cumulative incidence plot of the 5-component primary ISCHEMIA end-point using the primary MI (left upper panel) and secondary MI (right upper panel) definitions and the composite end-point of cardiovascular death or MI using the primary (left lower panel) and secondary (right lower panel) MI definitions by randomized treatment strategy. Choice of MI definition had an important impact on the outcome results. The secondary MI definition (right panels) was associated with an increased number of early procedural MI events in the invasive as compared with the conservative strategy. The difference between treatment groups attenuated over time using the secondary definition (right panel) primarily due to the increased number of spontaneous type 1 MI events in the conservative strategy. Cardiovascular death rates were low and not statistically different between treatment groups.