Table 2:
Death, Cardiovascular Death and the Composite of Cardiovascular Death or Hospitalization for Heart Failure Events Following an MI
| MI Type | No. MI Events | Event | No. Events Post-MI | HR (95% CI)* MI vs. No MI | P-value |
|---|---|---|---|---|---|
| Primary Definition | |||||
| Procedural MI | 89 | All-cause Death | 5 | 1.14 (0.42, 3.08) | 0.803 |
| Procedural MI (INV Only) | 67 | All-cause Death | 4 | 1.40 (0.51, 3.86) | 0.511 |
| Procedural MI (Excluding Stand-alone MI) | 36 | All-cause Death | 3 | 2.10 (0.67, 6.66) | 0.205 |
| Type 4B or 4C MI | 34 | All-cause Death | 5 | 3.99 (1.62, 9.83) | 0.003 |
| Type 1 MI | 217 | All-cause Death | 25 | 2.44 (1.54, 3.88) | <.001 |
| Procedural MI | 89 | Cardiovascular Death | 5 | 1.99 (0.73, 5.43) | 0.181 |
| Procedural MI (INV Only) | 67 | Cardiovascular Death | 4 | 2.77 (0.99, 7.76) | 0.052 |
| Procedural MI (Excluding Stand-alone MI) | 36 | Cardiovascular Death | 3 | 3.75 (1.17, 11.97) | 0.026 |
| Type 4B or 4C MI | 34 | Cardiovascular Death | 5 | 6.80 (2.73, 16.93) | <.001 |
| Type 1 MI | 217 | Cardiovascular Death | 21 | 3.38 (2.03, 5.61) | <.001 |
| Procedural MI | 89 | Cardiovascular Death or Hospitalization for Heart Failure | 5 | 1.45 (0.53, 3.93) | 0.469 |
| Procedural MI (INV Only) | 67 | Cardiovascular Death or Hospitalization for Heart Failure | 4 | 1.95 (0.71, 5.39) | 0.196 |
| Procedural MI (Excluding Stand-alone MI) | 36 | Cardiovascular Death or Hospitalization for Heart Failure | 3 | 2.61 (0.82, 8.28) | 0.103 |
| Type 4B or 4C MI | 34 | Cardiovascular Death or Hospitalization for Heart Failure | 8 | 7.82 (3.58, 17.84) | <.001 |
| Type 1 MI | 215 | Cardiovascular Death or Hospitalization for Heart Failure | 23 | 2.94 (1.82, 4.74) | <.001 |
| Secondary Definition | |||||
| Procedural MI | 245 | All-cause Death | 16 | 1.06 (0.56, 2.02) | 0.858 |
| Procedural MI (INV Only) | 204 | All-cause Death | 15 | 1.21 (0.63, 2.34) | 0.569 |
| Procedural MI (Excluding Stand-alone MI) | 115 | All-cause Death | 9 | 1.38 (0.61, 3.15) | 0.440 |
| Type 4B or 4C MI | 35 | All-cause Death | 5 | 3.69 (1.50, 9.09) | 0.005 |
| Type 1 MI | 223 | All-cause Death | 25 | 2.55 (1.60, 4.06) | <.001 |
| Procedural MI | 245 | Cardiovascular Death | 13 | 1.24 (0.57, 2.68) | 0.592 |
| Procedural MI (INV Only) | 204 | Cardiovascular Death | 12 | 1.54 (0.70, 3.43) | 0.286 |
| Procedural MI (Excluding Stand-alone MI) | 115 | Cardiovascular Death | 8 | 1.95 (0.79, 4.84) | 0.149 |
| Type 4B or 4C MI | 35 | Cardiovascular Death | 5 | 6.17 (2.48, 15.35) | <.001 |
| Type 1 MI | 223 | Cardiovascular Death | 21 | 3.52 (2.11, 5.88) | <.001 |
| Procedural MI | 245 | Cardiovascular Death or Hospitalization for Heart Failure | 15 | 1.16 (0.59, 2.30) | 0.661 |
| Procedural MI (INV Only) | 204 | Cardiovascular Death or Hospitalization for Heart Failure | 14 | 1.42 (0.70, 2.85) | 0.330 |
| Procedural MI (Excluding Stand-alone MI) | 115 | Cardiovascular Death or Hospitalization for Heart Failure | 10 | 2.00 (0.93, 4.31) | 0.077 |
| Type 4B or 4C MI | 35 | Cardiovascular Death or Hospitalization for Heart Failure | 8 | 7.07 (3.25, 15.38) | <.001 |
| Type 1 MI | 221 | Cardiovascular Death or Hospitalization for Heart Failure | 23 | 3.07 (1.90, 4.97) | <.001 |
*
Adjusted for the main ISCHEMIA trial covariates (age at randomization, sex, eGFR, ejection fraction, and diabetes) in addition to randomized treatment strategy, prior heart failure, prior MI, smoking status, LDL-C, and degree of ischemia. Continuous covariates are modeled as restricted cubic splines. The prognostic models flag an MI that occurs up to and on the day of the event of interest.