Table 1.
Participant demographics at baseline
| Combined cohort | AREDS cohort | AREDS2 cohort | |
|---|---|---|---|
| Participants | 8,130* | 4,504 | 3,738 |
| Mean age (years) | 71.0 (SD 6.7) | 69.3 (SD 5.1) | 72.9 (SD 7.7) |
| Female: n (%) | 4,593 (56.5) | 2,526 (56.1) | 2,129 (57.0) |
| Smoking status: n (%) | |||
| Never | 3,588 (44.1) | 2,021 (44.9) | 1,626 (43.5) |
| Former | 3,963 (48.7) | 2,142 (47.6) | 1,870 (50.0) |
| Current | 579 (7.1) | 341 (7.6) | 242 (6.5) |
| Body mass index: n (%) | |||
| ≤25 | - | 1,469 (32.6) | - |
| >25 and ≤30 | - | 1,889 (41.9) | - |
| >30 | - | 1,146 (25.4) | - |
| AMD severity category 3-4 (AREDS) or ≥7 | |||
| in worse eye (AREDS2): n (%) | |||
| No | - | 2,101 (46.6) | 887 (23.7) |
| Yes | - | 2,403 (53.4) | 2,851 (76.3) |
| Mean follow-up time (years) | 8.8 (SD 3.0) | 9.1 (SD 2.8) | 8.6 (SD 3.2) |
| Median 10.2 | Median 10.1 | Median 10.4 | |
| Participants with genetic data | 4,476 | 2,854 | 1,718 |
| Genetic risk score group: n (%) | |||
| Low risk groupt† | 1,183 (26.4) | 979 (34.3) | 226 (13.2) |
| Quartiles 1-2 | 1,659 (37.1) | 1,086 (38.1) | 610 (35.5) |
| Quartiles 3-4 | 1,634 (36.5) | 789 (27.6) | 882 (51.3) |
| ARMS2 risk alleles (rs10490924): n (%) | |||
| 0 (GG) | 2,071 (46.3) | 1,453 (50.9) | 665 (38.7) |
| 1 (GT) | 1,808 (40.4) | 1,106 (38.8) | 737 (42.9) |
| 2 (TT) | 597 (13.3) | 295 (10.3) | 316 (18.4) |
| CFH protective alleles (rs10922109): n (%) | |||
| 0 (CC) | 2,398 (53.6) | 1,300 (45.6) | 1,145 (66.6) |
| 1 (CA) | 1,637 (36.6) | 1,187 (41.6) | 486 (28.3) |
| 2 (AA) | 441 (9.9) | 367 (12.9) | 87 (5.1) |
| CFH risk alleles (rs1061170): n (%) | |||
| 0 (TT) | 1,140 (25.5) | 866 (30.3) | 299 (17.4) |
| 1 (TC) | 1,998 (44.6) | 1,305 (45.7) | 734 (42.7) |
| 2 (CC) | 1,338 (29.9) | 683 (23.9) | 685 (39.9) |
| C3 risk alleles (rs2230199): n (%) | |||
| 0 (CC) | 2,542 (56.8) | 1,672 (58.6) | 923 (53.7) |
| 1 (CG) | 1,656 (37.0) | 1,036 (36.3) | 658 (38.3) |
| 2 (GG) | 278 (6.2) | 146 (5.1) | 137 (8.0) |
Abbreviations: AMD=age-related macular degeneration; AREDS=Age-Related Eye Disease Study; ARMS2=age-related maculopathy susceptibility 2 gene; CFH=complement factor H gene; GA=geographic atrophy; SD=standard deviation
*
In the combined cohort, the 112 participants who were in both cohorts were counted only once (using their data from AREDS2)
†
Low risk genetic risk score group: participants whose genetic risk score was less than or equal to the mean genetic risk score of a control population without late age-related macular degeneration