Table 2.
Diseases related to mis-spliced lncRNAs
| Disease | lncRNA | Mechanism | References | |
|---|---|---|---|---|
| Cancer | Breast | PNUTS | Related to hnRNP E1, regulate the metastatic potential of tumor cells | 160 |
| AML | HOXB-AS3 | Regulates ribosomal RNA transcription in NPM1-mutated AML | 161 | |
| Ovarian cancer | MALAT1 | Knockdown MALAT1 in ovarian cancer leads to reduced expression of RNA-binding protein fox-1 homolog 2 (RBFOX2) to inhibit tumor cell proliferation | 162 | |
| CRC (colorectal cancer) | MALAT1 | Releasing SFPQ from SFPQ / PTBP2 complex by binding to SFPQ to promote tumor growth and migration | 163 | |
| LINC01133 | Interacting with SRSF6 to inhibit the EMT and metastasis | 164 | ||
| Lung | HOTAIR | Indicator of cell cycle dysregulation | 165 | |
| Adipogenesis | NEAT1 | Associates with SRp40 to regulate PPARγ2 Splicing | 166 | |
| Retinal cell | RNCR2 | Regulating retinal cell differentiation. | 167 | |
| Prader-Willi syndrome | SPA | Patterns of RBPs binding could be altered and alternative splicing. | 168 | |
| Alzheimer | 17A | Embedded in G-protein-coupled receptor 51 gene (GPR51), result the abnormal function of GABA B and alternative splicing | 169 |