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. 2021 Feb 23;12:1252. doi: 10.1038/s41467-021-21525-5

Fig. 8. A proposed model of VPS13D and ESCRTs function at mitochondria-LD MCSs.

Fig. 8

Upon starvation, VPS13D is accumulated at mitochondria-LD MCSs and mediates the ESCRT-dependent remodeling of LD membranes to facilitate FA transfer at these contacts. ESCRT, endosomal complexes required for transport; LD, lipid droplet; MCSs, membrane contact sites; OMM, outer mitochondrial membrane.