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. 2021 Feb 23;11:4343. doi: 10.1038/s41598-021-83827-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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EXACT’s three-tier architecture. Left: The data tier contains the PostgresSQL Docker container and the images, which can be saved within the Docker container or on the file system. Center: The application tier with the web-server Docker container instantiating Django instances with the corresponding modules. These modules handle images, annotations, users and plugin requests from the presentation tier and access the data tier to retrieve the stored information. NGINX works as a reverse proxy and handles EXACT’s load balancing. Right: The presentation tier contains the EXACT web client or third-party applications like SlideRunner, which send requests via the provided REST-API.