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. 2020 Jul 4;13(2):98–109. doi: 10.1093/inthealth/ihaa036

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© The Author(s) 2020. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Main effects of HIV infection on erythrocytes and platelets. (A) HIV infection leads to an increase in the prevalence of hyporegenerative anemia, which is evidenced by a decrease in both reticulocyte count and hemoglobin levels. Non-based antiretroviral therapy (ART) regimens restore hemoglobin levels and decrease anemia rates; however, zidovudine (ZDV)-based ART regimens induce anemia and macrocytosis. (B) HIV infection leads to an increase in the prevalence of thrombocytopenia, which may be the result of both the immune destruction of platelets in the periphery and the decrease in their production in bone marrow. ART regimens restore platelet count and decrease thrombocytopenia rates. MCV, mean corpuscular volume.