TABLE 1.
Nomenclature and function of IL-1 family members.
| Cytokine |
Primary receptor |
Co-receptor |
Effect | |||
| Name | Alternate name(s) | Name | Alternate name(s) | Name | Alternate name(s) | |
| IL-1α | IL-1F1 | IL-1R1/IL-1R2 (Decoy) | IL-1RAcP | IL-1R3 | Pro-inflammatory | |
| IL-1β | IL-1F2 | IL-1R1/IL-1R2 (Decoy) | IL-1RAcP | IL-1R3 | Pro-inflammatory | |
| IL-1Ra | IL-1F3 | IL-1R1 | Anti-inflammatory | |||
| IL-33 | IL-1F11 | IL-1R4 | ST2 | IL-1RAcP | IL-1R3 | Pro-inflammatory |
| IL-18 | IL-1F4 | IL-18Rα | IL-1R5 | IL-18Rβ | IL-1R7 | Pro-inflammatory |
| IL-37 | IL-1F7 | IL-18Rα | IL-1R5 | IL-1R8 | SIGIRR | Anti-inflammatory |
| IL-36α | IL-1F6 | IL-36R | IL-1Rrp2/IL-1R6 | IL-1RAcP | IL-1R3 | Pro-inflammatory |
| IL-36β | IL-1F7 | IL-36R | IL-1Rrp2/IL-1R6 | IL-1RAcP | IL-1R3 | Pro-inflammatory |
| IL-36γ | IL-1F8 | IL-36R | IL-1Rrp2/IL-1R6 | IL-1RAcP | IL-1R3 | Pro-inflammatory |
| IL-36Ra | IL-1F5 | IL-36R | IL-1Rrp2/IL-1R6 | Anti-inflammatory | ||
| IL-38 | IL-1F10 | IL-36R | IL-1Rrp2/IL-1R6 | Anti-inflammatory | ||