FIGURE 2.

(A) CD spectra of α-syn as a function of addition of lipid in the form of SUVs. From top to bottom, 10 μM α-syn without lipids, 10 μM α-syn with 1 mM lipids, 10 μM α-syn with 2 mM lipids, 10 μM α-syn with 3 mM lipids, and 10 μM α-syn with 4 mM lipids, respectively. The CD signal intensity reaches a maximum at a lipid: α-syn molar ratio of 300:1. (B) Cu²⁺ titration of the 10 μM α-syn−3 mM lipid complex. Cu²⁺ concentrations of 0, 10, and 100 μM give overlapping α-syn CD spectra. The figure and caption have been adapted with permission from Dudzik et al., (2013), Copyright ^© 2012 American Chemical Society.