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. 2021 Feb 10;13:637703. doi: 10.3389/fnagi.2021.637703

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Copyright © 2021 Hoshino, Uchinami, Uchida, Saito and Morimoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cecal ligation and puncture (CLP) impaired Schaffer-collateral CA1 LTP in SAMR1 but not in SAMP8. (A) Time course of the EPSP amplitudes in SAMR1 (upper left panel) and SAMP8 (upper right panel). Although LTP was not reduced in the SAMP8 + CLP group, post-tetanic potentiation was increased 1–4 min after high frequency stimulation (HFS). Representative examples in A were sampled at the labeled time points. (B) Scatter plots of the percentage of the mean EPSP amplitudes obtained 60 min after LTP induction, relative to the baseline in SAMR1 (lower left panel) and SAMP8 (lower right panel). Data are expressed as the mean ± standard deviation. SAMP8, Senescence-Accelerated Mice Prone 8; SAMR1, Senescence-Accelerated Resistant Mice 1; EPSP, excitatory postsynaptic potential; LTP, long-term potentiation.