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. 2021 Feb 10;12:616388. doi: 10.3389/fgene.2021.616388

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Copyright © 2021 Zhao, Tang, Wu, Li, Yi, Liu, Jiang, Wang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Workflow and molecular mechanism in this study. In this study, we constructed a short distance transportation stress model of beef cattle. Blood samples were collected and performed to RNA-seq, GO, KEGG, and WGCNA. Comparing with hematological and biochemical indices, we concluded that B cell function, lipid metabolism and steroid function were the mean molecular mechanism in short distance transportation stress of beef cattle. CD19 and CD40, the markers of B cell, were down-regulated in transcriptome data. The results of WGCNA showed that B cell function could be the core of transportation stress. After hub gene identification and qPCR verification, SMC3, JUN, and CXCL10 could be suggested as potential biomarkers for the diagnosis and recover of this condition.