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. 2021 Feb 10;15:635925. doi: 10.3389/fnins.2021.635925

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Copyright © 2021 Cao, Liu, Liu, Liu, Xu, Wang, Zhu, Wang, Li, Wen, Shen, Li, Nie and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The ASD gut microbiome is characterized by a significant reduction in butyrate-producing microbiota. (A,B) Differentially expressed fatty acid-associated metabolic functions predicted based on the 16s profile of the gut microbiota in subjects with ASD (n = 45) and healthy controls (n = 41). (C) Sum of butyrate-producing microbial taxa relative abundances in subjects with ASD (n = 45) and healthy controls (n = 41). Q- and p-values are labeled above the respective horizontal comparison lines.