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. 2021 Feb 10;15:628403. doi: 10.3389/fnins.2021.628403

FIGURE 1.

FIGURE 1

Female and male E4FAD− and E4FAD+ mice treated with high-dose candesartan had higher plasma levels of candesartan and lower blood pressure compared to vehicle. (A) Female and male E4FAD− and E4FAD+ mice treated with 10 mg/kg/day candesartan (high dose) had higher plasma drug levels than mice treated with vehicle (0 mg/kg/day) [Female E4FAD−: F(2, 6) = 13.38, p = 0.006. Female E4FAD+: F(2, 5) = 19.10, p = 0.0046. Male E4FAD−: F(2, 4) = 324.6, p < 0.0001. Male E4FAD+: F(2, 6) = 13.53, p = 0.006]. (B) Female and male E4FAD− and E4FAD+ mice treated with 10 mg/kg/day candesartan had lower mean arterial blood pressure at treatment endpoint compared to vehicle (Female E4FAD−: F(2, 19) = 6.54, p = 0.0069. Female E4FAD+: F(2, 22) = 11.95, p = 0.0003. Male E4FAD−: F(2, 20) = 14.04, p = 0.0002. Male E4FAD+: F(2, 24) = 4.56, p = 0.021). All data expressed as mean +/− SEM. *p < 0.05 by one-way ANOVA and Dunnet’s post-hoc analysis for candesartan dose compared to vehicle. See Supplementary Table 2 for details on n size and statistical comparisons.