Table 3.
Multilevel logistic models of the association between tertiles of IL6 and CRP and disordered eating behaviors and diagnoses at age 14, 16, and 18. Samples of participants with complete exposure and at least one outcome measurements (n = 3,480, imputed confounders and outcomes in those with at least one available).
| Outcomes | Exposure: thirds of IL-6 |
Exposure: thirds of CRP |
||
|---|---|---|---|---|
| 2nd third (vs 1st) OR (95%CI) of outcomes |
3rd third (vs 1st) OR (95%CI) of outcomes |
2nd third (vs 1st) OR (95%CI) of outcomes |
3rd third (vs 1st) OR (95%CI) of outcomes |
|
| Fasting | ||||
| Univariable | 1.68 (1.16, 2.45) p = 0.006 | 1.97 (1.24, 3.14) p = 0.004 | 2.22 (1.49, 3.29) p = 0.001 | 1.95 (1.22, 3.13) p = 0.006 |
| Multivariable model1 | 1.13 (0.77, 1.65) p = 0.53 | 1.06 (0.66, 1.71) p = 0.79 | 1.14 (0.77, 1.70) p = 0.52 | 0.65 (0.38, 1.10) p = 0.10 |
| Multivariable model2 | 1.05 (0.72, 1.53) p = 0.81 | 0.98 (0.62, 1.57) p = 0.94 | 1.14 (0.77, 1.69) p = 0.51 | 0.63 (0.38, 1.07) p = 0.09 |
| Dieting | ||||
| Univariable | 1.66 (1.19, 2.31) p = 0.003 | 2.36 (1.60, 3.47) p < 0.0001 | 2.67 (1.89, 3.76) p < 0.0001 | 4.05 (1.89, 3.76) p < 0.0001 |
| Multivariable model1 | 0.94 (0.68, 1.31) p = 0.73 | 0.91 (0.61, 1.35) p = 0.64 | 1.23 (0.87, 1.73) p = 0.23 | 0.96 (0.61, 1.50) p = 0.86 |
| Multivariable model2 | 0.92 (0.66, 1.28) p = 0.63 | 0.89 (0.60, 1.32) p = 0.56 | 1.23 (0.88, 1.73), p = 0.23 | 0.95 (0.61, 1.48), p = 0.81 |
| Binge eating | ||||
| Univariable | 1.21 (0.87, 1.68) p = 0.25 | 1.30 (0.87, 1.92) p = 0.20 | 1.43 (1.01, 2.01), p = 0.04 | 1.39 (0.90, 2.26) p = 0.14 |
| Multivariable model1 | 0.90 (0.65, 1.26) p = 0.56 | 0.83 (0.55, 1.25) p = 0.37 | 0.90 (0.64, 1.26) p = 0.54 | 0.61 (0.38, 1.00) p = 0.05 |
| Multivariable model2 | 0.87 (0.63, 1.21) p = 0.42 | 0.80 (0.53, 1.20) p = 0.27 | 0.91 (0.65, 1.28) p = 0.59 | 0.62 (0.39, 1.00) p = 0.05 |
| Purging | ||||
| Univariable | 1.53 (0.90, 2.56) p = 0.11 | 1.77 (0.90, 3.47) p = 0.09 | 1.95 (1.16, 3.32) p = 0.01 | 1.91 (1.00, 3.62) p = 0.05 |
| Multivariable model1 | 0.98 (0.58, 1.66) p = 0.94 | 0.94 (0.47, 1.85) p = 0.84 | 1.01 (0.60, 1.68) p = 0.98 | 0.63 (0.32, 1.26), p = 0.19 |
| Multivariable model2 | 0.95 (0.56, 1.60) p = 0.84 | 0.90 (0.46, 1.76) p = 0.76 | 1.03 (0.62, 1.70), p = 0.92 | 0.63 (0.32, 1.27), p = 0.20 |
| Exposure: thirds of IL-6 |
||||
| 2nd third (vs 1st) OR (95%CI) of outcomes |
3rd third (vs 1st) OR (95%CI) of outcomes |
2nd third (vs 1st) OR (95%CI) of outcomes |
3rd third (vs 1st) OR (95%CI) of outcomes |
|
| Any disordered eating | ||||
| Univariable | 1.58 (1.23, 2.01), p<0.0001 | 2.07 (1.55, 2.76),p<0.0001 | 1.88 (1.46, 2.41), p<0.0001 | 3.31 (1.72, 3.13), p<0.0001 |
| Multivariable model1 | 1.02 (0.80, 1.31), p=0.84 | 1.05 (0.80, 1.40), p=0.72 | 0.98 (0.76, 1.25), p=0.84 | 0.71 (0.51, 0.98), p=0.03 |
| Multivariable model2 | 0.99 (0.77, 1.25), p=0.91 | 1.00 (0.78, 1.25), p=0.97 | 0.98 (0.77, 1.25), p=0.87 | 0.70 (0.51, 0.97), p=0.03 |
| Anorexia Nervosa | ||||
| Univariable | 1.59 (0.60, 4.17) p=0.34 | 1.56 (0.52, 4.63) p=0.43 | 2.05 (0.85, 4.92) p=0.11 | 0.88 (0.25, 3.10) p=0.85 |
| Multivariable model1 | 1.35 (0.51, 3.64) p=0.54 | 1.28 (0.41, 3.96) p=0.67 | 1.47 (0.59, 3.59) p=0.41 | 0.65 (0.17, 2.44) p=0.52 |
| Multivariable model2 | 1.30 (0.49, 3.45) p=0.59 | 1.20 (0.39, 3.71) p=0.75 | 1.51 (0.62, 3.70) p=0.36 | 0.65 (0.18, 2.41) p=0.52 |
| Bulimia Nervosa | ||||
| Univariable | 1.21 (0.64, 2.28) p=0.55 | 1.32 (0.62, 2.81) p=0.47 | 2.50 (1.27, 4.96) p=0.009 | 1.36 (0.54, 3.47) p=0.52 |
| Multivariable model1 | 0.88 (0.43, 1.65), p=0.68 | 0.80 (0.37, 1.77), p=0.59 | 1.56 (0.22, 1.59) p=0.28 | 0.57 (0.21, 1.59) p=0.28 |
| Multivariable model2 | 0.84 (0.45, 1.59) p=0.59 | 0.76 (0.34, 1.67) p=0.49 | 1.54 (0.76, 3.09) p=0.23 | 0.55 (0.20, 1.55) p=0.25 |
| Binge eating disorder | ||||
| Univariable | 1.39 (0.68, 2.87) p=0.37 | 1.55 (0.66, 3.61) p=0.31 | 1.41 (0.70, 2.87) p=0.33 | 1.61 (0.66, 3.96) p=0.30 |
| Multivariable model1 | 0.97 (0.47, 2.00) p=0.93 | 0.83 (0.34, 2.02) p=0.68 | 0.80 (0.39, 1.64), p=0.55 | 0.60 (0.22, 1.61) p=0.31 |
| Multivariable model2 | 0.92 (0.44, 1.90) p=0.81 | 0.76 (0.31, 1.85) p=0.54 | 0.82 (0.40, 1.67) p=0.58 | 0.60 (0.22, 1.61) p=0.31 |
Multivariable model 1: adjusted for sex, time, and total fat mass in grams at age 9 years. Multivariable model 2: adjusted for sex, time, total fat mass in grams at age 9 years, maternal education, maternal age at child’s birth, maternal pre-pregnancy total fat mass in grams, maternal depression in pregnancy, mental health difficulties (i.e., total strength and difficulties questionnaire score) at age 7 years, peer victimization at age 8 years, maternal experience of stressful life events in pregnancy.