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. 2021 Feb 10;12:614949. doi: 10.3389/fphar.2021.614949

FIGURE 1.

FIGURE 1

Effects of PRE-084 treatment on spontaneous motor activity and gait patterns after SCI. Weight curves (A). Open field analysis of the distance covered in 8 min by mice in all groups (B). Walking pattern analysis using CatWalk XT® (C–H). Parameters analyzed include the regularity index (C) and the base of support (D). For paws located ipsilateral to the spinal cord lesion PRE-084 does not improve walking parameters such as the print position (E), the stride length (F) and the duty cycle (G). The paw angle of the hind paw located contralateral to the lesion is altered in the SCI-treated mice (H). Number of mice: Uninjured mice 6 (3 treated and three untreated, plain lines), hemisected mice 24 (12 treated and 12 untreated, dashed lines). Statistics: two-way ANOVA followed by Bonferroni tests in the comparison between injured control and injured treated groups (dashed lines), **p < 0.01.