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. 2021 Feb 10;12:614949. doi: 10.3389/fphar.2021.614949

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Copyright © 2021 Lattard, Poulen, Bartolami, Gerber and Perrin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lesion size analysis. Representative ex vivo diffusion weighted MRI (DWI) (A), toluidine blue staining (C) and luxol fast blue/neutral red staining (E) at lesion epicenter 6 weeks after SCI. Quantifications of the lesion percentage at the epicenter, the lesion extension and the lesion volume represented by area under the curve using DWI acquisitions (B), toluidine blue sections staining (D) and luxol fast blue/neutral red (F) in both treated and untreated injured animals. Note the damaged spinal cord tissue (outlined in red in C and E) used for lesion quantification and allows distinction from undamaged tissue (outlined in green in C and E) Number of hemisected mice: DWI six treated and six untreated and histology five treated and five untreated. Scale bars: A, C and E 600 μm.