TABLE 1.
Modulate autophagy compounds.
| Compound | In vitro/in vivo | Target | Regulate autophagy | Biological role | Refernces |
|---|---|---|---|---|---|
| STF-62247 | in vitro and in vivo | LC3-Ⅱ | Induce | Cell death (+) | Anbalagan et al. (2012) |
| Ubenimex | in vitro | LC3B | Induce | Cell death (+) | Liu et al. (2015) |
| (R)-goniothalamin and (S)-goniothalamin | in vitro | LC3B | Induce | Cell death (+) | de Fatima et al. (2008) |
| Silibinin | in vitro and in vivo | LC3-Ⅱ | Induce | Metastasis (−) | F. Li et al. (2015) |
| Resveratrol | in vitro | ATG5, ATG7 | Induce | Apoptosis (+) | Q. Liu et al. (2018) |
| Sinomenine | in vitro | Beclin1, LC3-Ⅱ/LC3-Ⅰ, p62 | Induce | Apoptosis (+) | F. Deng et al. (2018) |
| Rasfonin | in vitro | LC3-Ⅱ, p62 | Induce | Apoptosis (+), necroptosis (+) | Sun et al. (2016) |
| Chloroquine | in vitro | Deacidifying the lysosome | Inhibit | Apoptosis (+) | Grimaldi et al. (2015) |
| 3-Methyladenine | in vitro | LC3-Ⅱ | Inhibit | Apoptosis (+) | Zhang et al. (2013) |
| Bafilomycin A1 | in vitro | Deacidifying the lysosome | Inhibit | Apoptosis (+) | Zhang et al. (2013) |
(+) = increased, (-) = decreased.