TABLE 2.
Overrepresentation analysis using Consensus PathDB comparing differentially expressed genes in ginsenoside Rb2/Rg3 combination treated cells to control (10 pathways with lowest p-value are shown). Growth factor-involved signaling pathways, such as PDGF, EGFR1 and differentiation pathway, are overrepresented as well as cell survival pathways such as AP1, senescence and autophagy in cancer.
| p-value | q-value | Pathway | Source |
|---|---|---|---|
| 1.44 × 10−7 | 0.000149 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | Pathway interaction database (PID) Schaefer et al. (2009) |
| 8.07 × 10−7 | 0.000417 | Senescence and autophagy in cancer | Wikipathways Kelder et al. (2009) |
| 3.34 × 10−6 | 0.000856 | AGE-RAGE signaling pathway in diabetic complications - homo sapiens (human) | KEGG Kanehisa and Goto (2000) |
| 3.96 × 10−6 | 0.000856 | PDGF receptor signaling network | PID |
| 4.15 × 10−6 | 0.000856 | Hypertrophy model | Wikipathways |
| 5.11 × 10−6 | 0.000879 | Beta3 integrin cell surface interactions | PID |
| 6.06 × 10−6 | 0.000893 | EGFR1 | NetPath Kandasamy et al. (2010) |
| 1.20 × 10−5 | 0.00143 | Differentiation pathway | Wikipathways |
| 1.25 × 10−5 | 0.00143 | Nuclear receptors meta-pathway | Wikipathways |
| 1.44 × 10−5 | 0.00143 | Lung fibrosis | Wikipathways |