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. 2021 Feb 10;12:632810. doi: 10.3389/fgene.2021.632810

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Copyright © 2021 Wang, Xiong, Zhang, Sui, Yu, Liu, Li, Guo, Gao, Przepiorski, Davidson, Guo and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dynamic changes in metabolite-related genes. (A) Time-course expression profiles of 190 genes enriched in the KEGG term metabolic pathways. (B) KEGG functional analysis of three overrepresented clusters. Pathways with a P-value below 0.05 are shown. (C) Heatmap of relative gene expression related to OXPHOS from three overrepresented clusters. (D) Heatmap of relative gene expression in the TCA cycle related to OXPHOS and in the glycolysis pathway. Genes highlighted in the red frame encoding the rate-limiting enzymes. Heatmap shows averaged values from biological replicates.