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. 2021 Feb 10;15:604103. doi: 10.3389/fnins.2021.604103

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Copyright © 2021 Amaya, Suidgeest, Sahut-Barnola, Dumontet, Montanier, Pagès, Keller, van der Weerd, Pereira, Martinez and Meijer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of MBP in the dorsal hippocampus. Coded polygons in stained sections indicate neuroanatomical parcellations. (A,C–E) In CA1, AdKO_2.0 mice showed a decrease in MBP-positive areas in both sexes in oriens (O) and radiatum (R) strata and a male-specific decrease in the pyramidal layer, compared to WT mice. (B,F) In CA3, AdKO_2.0 mice showed a decrease compared to WT mice in expression in both sexes in the s. radiatum. (G,H) In the s. moleculare (M) and s. lucidum (L), a female-specific decrease was shown. S, G, and S × G: p value of the source of variation (sex, genotype, and interaction, respectively). Black dots: wild type. Gray squares: AdKO_2.0.