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. 2021 Feb 10;15:604103. doi: 10.3389/fnins.2021.604103

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Copyright © 2021 Amaya, Suidgeest, Sahut-Barnola, Dumontet, Montanier, Pagès, Keller, van der Weerd, Pereira, Martinez and Meijer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of Iba1 in the hippocampal CA3 (A) and DG (B). Coded polygons in stained sections indicate neuroanatomical parcellations. In the stratum moleculare (M) of CA3, AdKO_2.0 of both sexes showed a decrease in expression, compared to WT mice (C). In the polymorph (Po) layer of DG, there is a female-specific decrease in AdKO_2.0 mice (D). Data were analyzed by two-way ANOVA, α: 0.05. S, G, and S × G: p value of the source of variation (sex, genotype, and interaction, respectively). Black dots: wild type. Gray squares: AdKO_2.0.